Mucosal administration of α-fodrin inhibits experimental Sjögren's syndrome autoimmunity

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Mucosal administration of α-fodrin inhibits experimental Sjögren's syndrome autoimmunity

INTRODUCTION alpha-Fodrin is an autoantigen in Sjögren's syndrome. We hypothesized that mucosal administration of alpha-fodrin might prevent the disease. METHODS Four-week-old NOD mice were immunized (intranasal) with a 1 microg or 10 microg dose of alpha-fodrin every other day. PBS 10 microl/dose and Glutathione transferase (GST 10 microg/dose (control mice) were intranasally administrated b...

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ژورنال

عنوان ژورنال: Arthritis Research & Therapy

سال: 2008

ISSN: 1478-6354

DOI: 10.1186/ar2403